Anti-citrullinated α-Enolase antibody


Recognises α-enolase with a citrullinated arginine residue, a key target for auto-antibodies in rheumatoid arthritis

See full description

Application Data

Catalogue number crb2005010
Antibody Anti-citrullinated α-Enolase antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200290e
Protein ID UniProtKB - P06733
Cross-Reactivity Human, rat, chicken
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA
Target citrullinated α-Enolase
Disease Area Autoimmune
Family Enolase
Specificity Citrullinated form
Post-translational Modification Citrullination
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Citations Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, Mikuls TR, Venables PJ. (2008). Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 58(10):3009-19. PMID: 18821669.

Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J. and Venables, P. (2010). Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum, 62(9), 2662-2672. PMID: 20506214


Wegner, N., Wait, R. and Venables, P. (2009). Evolutionarily conserved antigens in autoimmune disease: Implications for an infective aetiology. Int J Biochem Cell Biol, 41(2), 390-397. PMID: 18926919

Alpha-enolase is an evolutionary conserved, multifunctional protein, best known for its role in glucose metabolism, and as a plasminogen-binding protein on the surface of various mammalian and prokaryotic cell types. Citrullinated α-enolase is one of the key targets for auto-antibodies in rheumatoid arthritis (RA) and such antibodies can be found in 40–60% of patients with RA. Citrullination is a post-translational modification of arginine residues, mediated by the family of peptidylarginine deiminases (PAD).

Anti-citrullinated α-Enolase antibody

Cat No. Pack Size Price Qty