Anti-sCTLA-4 antibody CRB4B8

Description

High affinity monoclonal antibody specifically targeting the soluble isoform of CTLA-4 (sCTLA-4)

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Catalogue number crb5005104
Antibody Anti-CTLA-4 antibody CRB4B8
Antigen Peptide KLH conjugated synthetic peptide crb1200373e
Protein ID UniProtKB - P16410
Aliases Cytotoxic T-lymphocyte protein 4, CD152 (cluster of differentiation 152
Cross-Reactivity Human
Host Species Mouse
Antibody Type Monoclonal
Concentration 1mg/ml
Validation WB/ELISA
Target sCTLA-4
Disease Area Immune homeostasis
Specificity Soluble CTLA-4
Storage This material is supplied in PBS, pH8 containing 1% trehalose. The product should be stored at +4°C for short term storage and -80°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Esposito, L., Hunter, K., Clark, J., Rainbow, D., Stevens, H., Denesha, J., Duley, S., Dawson, S., Coleman, G., Nutland, S., Bell, G., Moran, C., Pekalski, M., Todd, J. and Wicker, L. (2014). Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles. J Immunol, 193(2), 889-900. PMID: 24928993

 

Sekiya, T. and Takaki, S. (2019). RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4. Sci Rep, 9(1). PMID: 31061392

Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) in an immunoglobulin superfamily receptor important for downregulating immune responses. CTLA4 is expressed in T-cells where it transmits an inhibitory signal to the cells.

The secreted soluble form of CTLA-4 (sCTLA-4) lacks the transmembrane domain as well as the membrane proximal cysteine residue required for covalent homodimerization and therefore sCTLA-4 is only present in monomeric form.

In human and mouse sCTLA-4 mRNA expression is mainly detected in resting T-cells, at levels similar to transmembrane CTLA-4 (Tm-CTLA-4) mRNA, however following T-cell activation, Tm-CTLA-4 is upregulated and becomes the predominant transcript. Mutations in CTLA4 are associated with multiple autoimmune diseases, including type 1 diabetes (T1D), Graves’ disease (GD), rheumatoid arthritis and celiac disease, an increase of sCTLA-4 is also seen in autoimmune diseases.

Anti-sCTLA-4 antibody CRB4B8

Cat No. Pack Size Price Qty

crb5005104d

20µg

$225.00

crb5005104f

100µg

$375.00