Anti-Cyclin D1 antibody

Description

Recognises Cyclin D1, a key regulator of cell proliferation and tumourigenesis

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Application Data

Catalogue number crb2005024
Antibody Anti-Cyclin D1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200305e
Protein ID UnitProtKB - P24385
Aliases Cyclin D1
Cross-Reactivity Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Validation 1:500 (WB), 1:500 (ELISA)
Target Cyclin D1
Research Area Cancer, cell cycle
Family Cyclin
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Pysz, M., Hao, F., Hizli, A., Lum, M., Swetzig, W., Black, A. and Black, J. (2014). Differential Regulation of Cyclin D1 Expression by Protein Kinase C α and ϵ Signaling in Intestinal Epithelial Cells. J Biol Chem, 289(32), 22268-22283. PMID: 24914206

 

Qie, S. and Diehl, J. (2016). Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med, 94(12), 1313-1326. PMID: 27695879

Cyclin D1 is a key regulator of cell proliferation and its expression and accumulation within cells is under tight control. Cyclin D1 is the regulatory subunit of cyclin-dependent kinases 4 and 6. These activated cyclin dependent kinases then phosphorylate the retinoblastoma protein (Rb) and drive G1 to S phase progression. Cyclin D1 promotes cell proliferation through interaction with transcription factors such as the oestrogen receptor and specificity protein 1 (Sp1). Cell proliferation is extremely sensitive to altered levels of cyclin D1, with even modest changes in its expression having noticeable effects on cell cycle progression.

Cyclin D1 is a proto-oncogene and its overexpression is one of the most frequent alterations seen in multiple cancer types.

Anti-Cyclin D1 antibody

Cat No. Pack Size Price Qty

crb2005024d

20ug

$150.00

crb2005024f

100ug

$300.00