Anti-FGFR2b antibody

Description

Recognises fibroblast growth factor receptor 2b epithelial splice variant, a receptor tyrosine kinase involved in cell growth and survival

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Application Data

Catalogue number crb2005089
Antibody Anti-FGFR2b antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200370e
Protein ID UniProtKB -
Aliases Fibroblast growth factor receptor 2b, FGFR2b, Keratinocyte growth factor receptor, CD332
Cross-Reactivity Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:100 (WB), 1:1000 (ELISA)
Target FGFR2b
Research Area Signal transduction
Family Fibroblast growth factor receptor subfamily
Super Family Tyrosine protein kinase family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

MacKenzie, B., Henneke, I., Hezel, S., Al Alam, D., El Agha, E., Chao, C., Quantius, J., Wilhelm, J., Jones, M., Goth, K., Li, X., Seeger, W., Königshoff, M., Herold, S., Rizvanov, A., Günther, A. and Bellusci, S. (2015). Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol, 308(10), 1014-L1024. PMID: 25820524

 

Nanni, M., Ranieri, D., Raffa, S., Torrisi, M. and Belleudi, F. (2017). Interplay between FGFR2b-induced autophagy and phagocytosis: role of PLCγ-mediated signalling. J Cell Mol Med, 22(1), 668-683. PMID: 28994193

The fibroblast growth factor receptor (FGFR) family consists of four transmembrane receptor tyrosine kinases (FGFR1‐4), which regulate important physiological processes, such as cell proliferation, differentiation, migration and survival throughout the body. FGFR2b is known as the epithelial FGFR2 isoform.

FGFR2b/KGFR is exclusively expressed in epithelial cells and can be activated by stimulation with its specific ligands FGF7/KGF or FGF10. Ligand binding results in a signalling cascade which includes phosphoinositide 3‐kinase (PI3K) and mitogen‐activated protein kinase (MAPK) signalling pathways and/or activation of phospholipase C-γ (Plc-γ). FGFR2b activation culminates in the survival, growth, and differentiation of epithelial cells, triggers phagocytosis and melanosome uptake in human keratinocytes and is critical for proper craniofacial development.

Anti-FGFR2b antibody

Cat No. Pack Size Price Qty

crb2005089d

20µg

$150.00

crb2005089f

100µg

$300.00