Anti-GPRC5B antibody

Description

Antibody raised against GPRC5B, a protein used in G-protein signalling pathways, involved in cell migration through positive regulation of WNT pathway.

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Catalogue number crb2005670
Antibody Anti-GPRC5B antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200878e
Protein ID Q9NZH0 GPRC5B
Aliases G-protein coupled receptor family C group 5 member B, A-69G12.1, Retinoic acid-induced gene 2 protein, RAIG-2
Host Species Rabbit
Antibody Type Polyclonal
Concentration 2.5mg/ml Glycine (R1G), 2.5mg/ml Glycine (R2G)
Target GPRC5B
Family G-protein coupled receptor 3 family
Storage The product should be stored at -20°C for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
References

Chung, H.-J., et al. (2014). G protein-coupled receptor, family C, group 5 (GPRC5B) downregulation in spinal cord neurons is involved in neuropathic pain. Korean Journal of Anesthesiology, 66(3), pp.230–236.

 

Hirabayashi, Y. and Kim, Y.-J. (2020). Roles of GPRC5 family proteins: Focusing on GPRC5B and lipid-mediated signaling. The Journal of Biochemistry, 167(6).

 

Robbins, M.J., et al. (2000). Molecular Cloning and Characterization of Two Novel Retinoic Acid-Inducible Orphan G-Protein-Coupled Receptors (GPRC5B and GPRC5C). Genomics, 67(1), pp.8–18.

G-Protein Coupled Receptor Family C Group 5 Member B (GPRC5B), also knowns as RAIG2) is a member of the type 3 G protein-coupled receptor superfamily, characterised by the signature 7-transmembrane domain motif. In mammals, GPRC5 receptors have been shown to include four subtypes: GPRC5A (RAIG1), GPRC5B (RAIG2), GPRC5C (RAIG3) and GPRC5D. It is a retinoic acid-inducible G-protein coupled receptor, with the potential to provide evidence for an interaction between retinoid and G-protein signalling pathways.
It is predicted to be involved in cell migration, through positive regulation of the WNT signalling pathway, and in localisation of proteins to the extracellular cell surface membrane. GPRC5B is an all-trans retinoic acid gene, suggested to be involved in neuronal cell differentiation, tubulogenesis and renal regeneration.

Anti-GPRC5B antibody

Cat No. Pack Size Price Qty

crb2005670d/R1G

R1G 20ug

$75.00

crb2005670d/R2G

R2G 20ug

$75.00