Anti-PERK antibody


Recognizes integrated stress response (ISR) kinase, PERK

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Application Data

Catalogue number crb2005276
Antibody Anti-PERK antibody
Antigen Peptide Drosophila PERK kinase domain recombinant protein
Protein ID UniProtKB - Q9NIV1 (E2AK3_DROME)
Aliases Drosophila PEK (pancreatic eIF2α kinase), CG2087, Drosophila Eukaryotic translation initiation factor 2-alpha kinase (E2AK3)
Cross-Reactivity Drosophila melanogaster
Host Species Rabbit
Antibody Type Polyclonal
Concentration antiserum
Validation 1:1000 (WB)
Disease Area Unfolded protein response, Wolcott Rallison Syndrome / diabetes mellitus
Family serine/threonine kinases
Super Family eIF2α kinases

Malzer et al., (2010). Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. J Cell Sci. 1: 123(17): 2892. PMID: 20682638

Recognizes Integrated stress response (ISR) kinase, PERK, with a strong signal and low background noise.

When there are a large number of misfolded proteins in the cell a homeostatic mechanism called the unfolded protein response (UPR) is activated which involves restricting translation and increasing chaperone capacity. As part of this response, the ER-resident kinase PERK (eukaryotic translation initiation factor 2α kinase, also known as PEK) phosphorylates the translation initiation factor eIF2α resulting in the attenuation of translation.

PERK activation causes loss of cyclin D1 and G1 cell cycle arrest, negatively regulating cell proliferation. PERK-dependent activation of GSK3β during ER stress has been shown to destabilise p53.

Anti-PERK antibody

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