Anti-RAMP2 antibody

Description

Recognises C-terminal region of RAMP2, a receptor accessory protein in Western blots and immunohistochemistry with a strong signal and low background noise

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Application Data

Catalogue number crb2005160
Antibody Anti-RAMP2 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200418e
Protein ID UniProtKB - O60895
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:40 (WB), 1:200 (IF), 1:1000 (ELISA)
Target RAMP2
Family RAMP family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

McLatchie et al., (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature.393(6683): 333. PMID: 9620797

 

Weston et al., (2015). Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2). J Biol Chem.290(38): 23009. PMID: 26198634

Receptor activity-modifying protein 2 (RAMP2) is a receptor accessory protein that alters the pharmacology of G-protein coupled receptors (GPCRs). RAMP2 associates with GPCRs to alter ligand specificity and mediate receptor trafficking. RAMP2 forms a receptor complex with calcitonin receptor-like receptor (CRLR) known as the calcitonin gene-related protein (CGRP) receptor. RAMP2 is responsible for the transport of this receptor to the plasma membrane.

RAMPs also associate with other family B G-protein coupled receptors including the calcitonin receptor, the vasoactive intestinal polypeptide/pituitary AC-activating peptide 1 (VPAC1) receptor, and the glucagon receptor (GCGR) where they modulate ligand and G-protein selection.

Anti-RAMP2 antibody

Cat No. Pack Size Price Qty

crb2005160d

20ug

$165.00

crb2005160f

100ug

$330.00