Anti-SARS-CoV-2 Spike protein antibody

Description

Recognises SARS-CoV-2 Spike protein polybasic cleavage site

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Application Data

Catalogue number crb2005280
Antibody Anti-SARS-CoV-2 Spike protein antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200514e
Aliases Coronavirus, SARS-CoV-2, Covid-19
Cross-Reactivity Virus
Host Species Rabbit
Antibody Type Polyclonal
Concentration 0.5 mg/ml
Target SARS-CoV-2 Spike protein
Specificity Recognises SARS-CoV-2 Spike protein polybasic cleavage site
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Byrnes et al., (2020). Competitive SARS-CoV-2 Serology Reveals Most Antibodies Targeting the Spike Receptor-Binding Domain Compete for ACE2 Binding. mSphere. 5(5): e00802-20. PMID: 32938700

 

Wang et al., (2020). Molecular simulation of SARS-CoV-2 spike protein binding to pangolin ACE2 or human ACE2 natural variants reveals altered susceptibility to infection. J Gen Virol. 101(9): 921. PMID: 32538738

The SARS-CoV2 is a novel coronavirus identified as the cause of the coronavirus disease 2019 (COVID-19) pandemic that began in Wuhan, China in 2019. SARS-CoV-2 can cause severe diseases such as pneumonia, acute respiratory distress syndrome (ARDS), sepsis, septic shock or multiple organ failure, particularly among the elderly and immunocompromised patients. SARS-CoV-2 virus particles are round, elliptic and often pleomorphic in shape and a diameter of approximately 60–140 nm. The SARS-CoV2 genome encodes four essential structural proteins including the spike (S) glycoprotein, nucleocapsid (N) protein, membrane (M) protein, and the envelope (E) protein, and also several accessory proteins.

The SARS-CoV-2 spike protein is present on the outside of the virus particles and is able to bind to angiotensin-converting enzyme II (ACE2) present on the host cells. The C-terminal receptor binding domain (RBD) of the spike protein binds to the N-terminal peptidase M2 domain of ACE2. This receptor binding results in internalisation of the virus-receptor complex and is therefore the mechanism of entry of SARS-CoV-2 into host cells.

Anti-SARS-CoV-2 Spike protein antibody

Cat No. Pack Size Price Qty

crb2005280d

20ug

$165.00

crb2005280f

100ug

$330.00