Anti-Cache Valley Virus (CVV) Nucleocapsid antibody


Recognises the viral capsid protein which encloses the nucleocapsids of Cache Valley virus and Batai virus

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Application Data

Catalogue number crb2005018
Antibody Anti-Cache Valley Virus (CVV) Nucleocapsid antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200003e
Protein ID UniProtKB - D6MXQ7
Cross-Reactivity Cache Valley Virus, Batai virus
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation WB/ELISA
Target Cache Valley Virus
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Citations Dunlop et al., (2018) Development of reverse genetics systems and investigation of host response antagonism and reassortment potential for Cache Valley and Kairi viruses, two emerging orthobunyaviruses of the Americas. PLoS Negl Trop Dis. 12(10):e0006884. doi: 10.1371/journal.pntd.0006884. PMID: 30372452.

Wilson et al., (2017). A novel cause of chronic viral meningoencephalitis: Cache Valley virus. Ann Neurol, 82(1), 105-114. PMID: 28628941


Hoffmann et al., (2013). Ovine Fetal Immune Response to Cache Valley Virus Infection. J Virol, 87(10), 5586-5592. PMID: 23468505

Cache Valley virus (CVV) belongs to the Peribunyaviridae family of viruses (previously called Bunyaviridae) and is a mosquito born virus which is widespread throughout North and Central America. CVVs preferred mosquito vectors include several species of Aedes and it infects many species of domestic sheep and cattle. CVV infection in sheep causes spontaneous abortion, stillbirth, and congenital defects. The virus is neuroinvasive in humans and can cause central nervous system (CNS) diseases, such as encephalitis and meningitis and in rare cases has caused death. There appears to be a high infection rate (up to 18% of population) in virus-endemic areas. This antibody recognises the nucleocapsid protein in Cache Valley virus and Batai virus but not other members of the Bunyamwera serogroup such as Kairi virus and Bunyamwera virus.

Anti-Cache Valley Virus (CVV) Nucleocapsid antibody

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