Anti-crc antibody

Description

Recognises the Drosophila cryptocephal protein, a bZIP transcription factor involved in insect moulting behaviour

See full description

Application Data

Catalogue number crb2005253
Antibody Anti-crc antibody
Antigen Peptide Recombinant protein
Protein ID UniProtKB - Q9VID3_DROME
Aliases Cryptocephal, dATF4
Cross-Reactivity UniProtKB - Q9VID3_DROME
Host Species Rabbit
Antibody Type Polyclonal
Concentration serum
Validation WB (1:1000), ELISA (1:1000)
Target Cryptocephal
Citations Malzer E., Dominicus C.S., Chambers J.E., Dickens J.A., Mookerjee S., Marciniak S.J. (2018). The integrated stress response regulates BMP signalling through effects on translation. BMC Biology 16:34. PMID: 29609607
Research Area Cell stress signalling, Integrated stress response, Unfolded protein response, Developmental signalling, Coffin-Lowry Syndrome, Leukoencephalopathy With Vanishing White Matter, Inflammatory bowel disease
Family basic-leucine zipper transcription factors, CREB/ATF family of basic-leucine zipper transcription factors
Specificity Protein
Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles.
References

Gauthier, S., Van Haaften, E., Cherbas, L., Cherbas, P. and Hewes, R. (2012). Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2. PLoS Genet, 8(8), e1002883. PMID: 22912598

 

Hewes RS1, Schaefer AM, Taghert PH. (2000). The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics. 155(4), 1711-1723. PMID: 10924469

Cryptocephal (CRC) is a basic-leucine zipper (bZIP) transcription factor in Drosophila and the homologue of vertebrate activating transcription factor 4 (ATF4), a member of the CREB/ATF family of transcription factors. CRC interacts with EcR-B2 to promote ecdysone-dependent expression of ecdysis triggering hormone (ETH), an essential regulator of insect moulting behaviour.

The crc gene is expressed throughout development and mutations in crc causes pleiotropic defects in ecdysone-regulated events during Drosophila moulting and metamorphosis. In third instar larvae, crc expression is high in targets of ecdysone signalling, such as the leg and wing imaginal discs and in the ring gland, where ecdysone is produced.

Anti-crc antibody

Cat No. Pack Size Price Qty

crb2005253d

20ul

$150.00

crb2005253f

100ul

$300.00