Anti-IL-11 antibody

Description

Recognises IL-11, a multifunctional haematopoietic cytokine implicated in several normal and pathological processes

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Application Data

Catalogue number crb2005041
Antibody Anti-IL-11 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200323e
Protein ID UniProtKB - P20809
Aliases Interleukin-11, adipogenesis inhibitory factor
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:500 (WB), 1:1000 (ELISA)
Target IL-11
Disease Area Inflammatory
Family Cytokines (IL-6)
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Tao, L., Huang, G., Wang, R., Pan, Y., He, Z., Chu, X., Song, H. and Chen, L. (2016). Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. Sci Rep, 6(1). PMID: 27922075

 

Sokolov, A., Kazakov, A., Solovyev, V., Ismailov, R., Uversky, V., Lapteva, Y., Mikhailov, R., Pavlova, E., Terletskaya, I., Ermolina, L., Permyakov, S. and Permyakov, E. (2016). Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules, 21(12), 1632. PMID: 27916836

Interleukin-11 (IL-11) is a multifunctional haematopoietic cytokine implicated in several normal and pathological processes. It belongs to the interleukin-6 (IL-6) family of cytokines, which affect intracellular signalling pathways via interaction with the ubiquitously expressed signal-transducing receptor, gp130 and a non-signalling cytokine-specific receptor.

IL-11 is expressed in hepatocytes, B cells, macrophages and osteoclasts and it activates JAK/STAT and MAPK signalling pathways, exerting in some cases drastically different physiological effects. IL-11 favours oncogenesis in numerous overlapping cancer types such as gastrointestinal cancers, breast cancer and osteosarcoma. IL-11 has growth factor activity, immunological activity and plays a role in female fertility control. IL-11 is under investigation for treatment of rheumatoid arthritis, Crohn’s disease, and other inflammatory conditions.

Anti-IL-11 antibody

Cat No. Pack Size Price Qty

crb2005041d

20ug

$150.00

crb2005041f

100ug

$300.00