Alexa Fluor® 488 Anti-Lamin A/C antibody

$375.00

Description

Recognises human lamin A and C in both Western blots and immunohistochemistry with strong signal and low background. Conjugated to Alexa Fluor® 488 fluorescent dye

See full description

Catalogue number crb2115011e
Antibody Alexa Fluor® 488 Anti-Lamin A/C antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200292e
Protein ID UnitProtKB - Q8N519
Cross-Reactivity Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration 0.57mg/ml
Validation ELISA
Target Lamin A/C
Disease Area Limb-Girdle muscular dystrophy
Family Intermediate filament (Lamins)
Specificity Protein
Storage Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References

Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes.  J Cell Biol, 211(3), 533-551. PMID: 26553927

 

Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401

Nuclear lamin proteins (lamin A, B and C) form a complex structural scaffold, called the nuclear lamina, which is associated with the inside of the nuclear envelope.

Lamins bind to a huge number of nuclear protein complexes and are involved in several processes, including chromatin organisation, gene regulation, genome stability, nuclear and cytoskeletal organisation, mechanical stability, differentiation, and tissue-specific functions. Mutations in lamin proteins result in laminopathies such as muscular dystrophy and the accelerated aging condition, Hutchinson-Gilford progeria.

This antibody recognises human lamin A and C in both Western blots and immunohistochemistry with a strong signal and low background noise, and has an Alexa Fluor® 488 dye conjugated to it. Alexa Fluor® 488 is a popular, bright green, PH-stable fluorescent dye.

Alexa Fluor® 488 Anti-Lamin A/C antibody