Alexa Fluor® 488 Anti-Lamin A/C antibody



Recognises human lamin A and C in both Western blots and immunohistochemistry with strong signal and low background. Conjugated to Alexa Fluor® 488 fluorescent dye

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Catalogue number crb2115011e
Antibody Alexa Fluor® 488 Anti-Lamin A/C antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200292e
Protein ID UnitProtKB - Q8N519
Cross-Reactivity Human
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration 0.57mg/ml
Validation ELISA
Target Lamin A/C
Disease Area Limb-Girdle muscular dystrophy
Family Intermediate filament (Lamins)
Specificity Protein
Storage Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C

Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes.  J Cell Biol, 211(3), 533-551. PMID: 26553927


Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401

Nuclear lamin proteins (lamin A, B and C) form a complex structural scaffold, called the nuclear lamina, which is associated with the inside of the nuclear envelope.

Lamins bind to a huge number of nuclear protein complexes and are involved in several processes, including chromatin organisation, gene regulation, genome stability, nuclear and cytoskeletal organisation, mechanical stability, differentiation, and tissue-specific functions. Mutations in lamin proteins result in laminopathies such as muscular dystrophy and the accelerated aging condition, Hutchinson-Gilford progeria.

This antibody recognises human lamin A and C in both Western blots and immunohistochemistry with a strong signal and low background noise, and has an Alexa Fluor® 488 dye conjugated to it. Alexa Fluor® 488 is a popular, bright green, PH-stable fluorescent dye.

Alexa Fluor® 488 Anti-Lamin A/C antibody