Alexa Fluor® 488 Anti-mGluR1 antibody

$375.00

Description

Recognises metabotropic glutamate receptor 1, a G protein-coupled receptor involved in glutamate neurotransmission. Conjugated to Alexa Fluor® 488 fluorescent dye

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Catalogue number crb2115006e
Antibody Alexa Fluor® 488 Anti-mGluR1 Antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200278e
Protein ID UniProtKB - Q13255
Aliases GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, protein phosphatase 1 regulatory subunit 85
Cross-Reactivity Rat, Mouse
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration 0.34mg/ml
Validation ELISA
Target mGluR1
Research Area Neurodegenerative diseases
Family G-protein coupled receptor 3 family
Specificity Protein
Storage Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References

Bakshi, K., Parihar, R., Goswami, S., Walsh, M., Friedman, E. and Wang, H. (2014). Prenatal Cocaine Exposure Uncouples mGluR1 from Homer1 and Gq Proteins. PLoS ONE, 9(3), e91671. PMID: 24626340

 

Lopez-Chiriboga, A., Komorowski, L., Kümpfel, T., Probst, C., Hinson, S., Pittock, S. and McKeon, A. (2016). Metabotropic glutamate receptor type 1 autoimmunity. Neurology, 86(11), 1009-1013. PMID: 26888994

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.

Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, Homer.

mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber–Purkinje cell synapses critical for cerebellar motor learning.

This antibody is conjugated to Alexa Fluor® 488, a popular bright green fluorescent dye with high pH-stability.

Alexa Fluor® 488 Anti-mGluR1 antibody