Alexa Fluor® 488 Anti-MRGPR-X1 antibody

$375.00

Description

Recognises MRGPR-X1 in rat and mouse, MRGPR-X1 is a receptor involved in inducing acute pain. Conjugated to Alexa Fluor® 488 fluorescent dye.

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Catalogue number crb2115053e
Antibody Alexa Fluor® 488 Anti-MRGPR-X1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200340e
Protein ID UniProtKB - Q8R4G1
Cross-Reactivity Rat, Mouse
Host Species Anti-Rabbit
Antibody Type Polyclonal
Concentration 0.78mg/mL
Validation ELISA
Target MRGPR-X1
Disease Area Inflammatory, Neurological, Cancer
Family MAS Related GPR Family
Specificity Protein
Storage Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References

Solinski, H., Petermann, F., Rothe, K., Boekhoff, I., Gudermann, T. and Breit, A. (2013). Human Mas-Related G Protein-Coupled Receptors-X1 Induce Chemokine Receptor 2 Expression in Rat Dorsal Root Ganglia Neurons and Release of Chemokine Ligand 2 from the Human LAD-2 Mast Cell Line. PLoS ONE, 8(3), e58756. PMID: 23505557

 

Solinski, H., Zierler, S., Gudermann, T. and Breit, A. (2012). Human Sensory Neuron-specific Mas-related G Protein-coupled Receptors-X1 Sensitize and Directly Activate Transient Receptor Potential Cation Channel V1 via Distinct Signaling Pathways. J Biol Chem, 287(49), 40956-40971. PMID: 23074220

Primate-specific Mas-related G protein-coupled receptor-X1 (MRGPR-X1) is highly enriched in dorsal root ganglia (DRG) neurones as well as in connective tissue mast cells (CTMC) and the leukaemia-derived human mast cell line (LAD)-2. MRGPR-X1 activation induces acute pain and therefore represents a promising target for future pain therapy.

MRGPR-X1 is activated by bovine adrenal medulla peptide-8-22 (BAM 8–22) which is cleaved from pro-enkephalin by pro-hormone convertases. Unlike most if not all Gq-coupled receptors MRGPR-X1 does not undergo agonist-promoted endocytosis.

This antibody is conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a popular bright green fluorescent dye with high pH-stability.

Alexa Fluor® 488 Anti-MRGPR-X1 antibody