Anti-citrullinated α-Enolase antibody

Description

Recognises α-enolase with a citrullinated arginine residue, a key target for auto-antibodies in rheumatoid arthritis

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Application Data

Catalogue number crb2005010
Antibody Anti-citrullinated α-Enolase antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200290e
Protein ID UniProtKB - P06733
Cross-Reactivity Human, rat, chicken
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA
Target citrullinated α-Enolase
Disease Area Autoimmune
Family Enolase
Specificity Citrullinated form
Post-translational Modification Citrullination
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J. and Venables, P. (2010). Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum, 62(9), 2662-2672. PMID: 20506214

 

Wegner, N., Wait, R. and Venables, P. (2009). Evolutionarily conserved antigens in autoimmune disease: Implications for an infective aetiology. Int J Biochem Cell Biol, 41(2), 390-397. PMID: 18926919

Alpha-enolase is an evolutionary conserved, multifunctional protein, best known for its role in glucose metabolism, and as a plasminogen-binding protein on the surface of various mammalian and prokaryotic cell types. Citrullinated α-enolase is one of the key targets for auto-antibodies in rheumatoid arthritis (RA) and such antibodies can be found in 40–60% of patients with RA. Citrullination is a post-translational modification of arginine residues, mediated by the family of peptidylarginine deiminases (PAD).

Anti-citrullinated α-Enolase antibody

Cat No. Pack Size Price Qty

crb2005010d

20ug

$150.00

crb2005010e

100ug

$300.00