Anti-ERK1/2 antibody

Description

Recognises ERK1/2 a MAPK family protein which controls cell proliferation

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Application Data

Catalogue number crb2005025
Antibody Anti-ERK1/2 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200306e
Protein ID UniProtKB - P27361
Aliases Extracellular Signal-Related Kinase 1, ERK1, ERK-1, ERK2, ERK-2, Mitogen-Activated Protein Kinase 3, MAP Kinase 3, MAPK 3.
Cross-Reactivity Human, Rat, Mouse
Host Species Anti-Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target ERK1/2
Family Mitogen-activated protein (MAP) kinases family
Specificity ERK1 and ERK2
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Cook, S., Stuart, K., Gilley, R. and Sale, M. (2017). Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling. FEBS J, 284(24), 4177-4195. PMID: 28548464

 

Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R. and Huang, D. (2018). Mechanisms shaping the role of ERK1/2 in cellular senescence (Review). Mol Med Rep, 19(2), 759–770. PMID: 30535440

Santa_Cruz_alternative sc-93, sc-514302
Extracellular signal-regulated kinase 1/2 (ERK1/2) is a mitogen-activated protein kinase (MAPK) family protein and part of the Ras-Raf‐MEK‐ERK signalling pathway which plays a key role in controlling cell proliferation, differentiation and cell survival. ERK1/2 acts downstream of activated growth factor receptors, RAF protein kinases and mitogen-activated protein kinase kinases 1 and 2 (MEK1/2). MEK1 and MEK2 activate ERK1/2 by phosphorylation and once activated ERK1/2 enters the nucleus and phosphorylates transcription factors to induce changes in gene expression. In addition to this active ERK1/2 also translocates to other organelles including the endoplasmic reticulum, endosomes, golgi and mitochondria where it influences cell physiology. Overall ERK1/2 phosphorylates more than 200 different substrates including other protein kinases, transcription factors, RNA‐binding proteins, regulators of mRNA translation and regulators of cell death. ERK1/2 pathway is strongly implicated in cancer where its hyperactivation underpins the growth and maintenance of many tumour types.

Anti-ERK1/2 antibody

Cat No. Pack Size Price Qty

crb2005025d

20ug

$150.00

crb2005025f

100ug

$300.00