Anti-GLT-1 antibody

Description

Recognises GLT1, the major glutamate transporter in the brain in rat, with human and mouse cross reactivity

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Application Data

Catalogue number crb2005049
Antibody Anti-GLT-1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200000e
Protein ID SwissProt - P60709
Aliases GLT1, EAAT2 , Excitotoxic Amino Acid Transporter 2, Excitatory Amino Acid Transporter 2, Solute Carrier Family 1 Member 2, Sodium-Dependent Glutamate/Aspartate Transporter 2, Glutamate/Aspartate Transporter II
Cross-Reactivity Mouse, Human
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target GLT-1
Disease Area Neurodegenerative diseases
Family Glutamate transporter
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Al Awabdh, S., Gupta-Agarwal, S., Sheehan, D., Muir, J., Norkett, R., Twelvetrees, A., Griffin, L. and Kittler, J. (2016). Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures. Glia, 64(7), 1252-1264. PMID: 27189737

 

Meabon, J., Lee, A., Meeker, K., Bekris, L., Fujimura, R., Yu, C., Watson, G., Pow, D., Sweet, I. and Cook, D. (2011). Differential Expression of the Glutamate Transporter GLT-1 in Pancreas. J Histochem Cytochem, 60(2), 139-151. PMID: 22114258

Santa_Cruz_alternative sc-15317, sc-7760
Glutamate transporter 1 (GLT-1) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. GLT-1 is best understood for its critical role in preventing neuronal excitotoxicity and brain seizures in the central nervous system (CNS). Maintaining the correct level of extracellular glutamate is crucial for neuronal transmission and network activity.

Glutamate uptake function allows GLTs/EAATs to terminate and shape excitatory synaptic transmission, and prevent neuronal excitotoxicity.Increasing evidence argues that GLT-1 also modulates, and is modulated by, metabolic processes that influence glucose homeostasis

Anti-GLT-1 antibody

Cat No. Pack Size Price Qty

crb2005049d

20ug

$150.00

crb2005049f

100ug

$300.00