Anti-Histone H2B antibody

Description

Recognises histone H2B, one of the four core histone proteins

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Application Data

Catalogue number crb2005165
Antibody Anti-Histone H2B antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200311e
Protein ID UniProtKB - P62807
Aliases Histone H2B type 1-C/E/F/G/I
Cross-Reactivity Human, Rabbit, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA),
Target Histone H2B
Research Area Histones
Family Histones
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Cole, A., Clifton-Bligh, R. and Marsh, D. (2014). Histone H2B monoubiquitination: roles to play in human malignancy. Endoc-Related Cancer, 22(1), T19-T33. PMID: 24891457

Khan, M., Alam, K., Hassan, S. and Rizvi, M. (2017). Nitration of H2B histone elicits an immune response in experimental animals. Autoimmunity, 50(4), 232-240. PMID: 28737980

Mao, P., Kyriss, M., Hodges, A., Duan, M., Morris, R., Lavine, M., Topping, T., Gloss, L. and Wyrick, J. (2016). A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res, 44(19), 9142–9152. PMID: 27369377

Antibody which recognises human histone H2B. H2B is one of the four core histone proteins which make up the protein core of the nucleosome around which DNA is wound to form the basic unit of chromatin. H2B, like other histone proteins is highly conserved across species with even distantly related species having high levels of sequence homology. Post translational modifications of histones such as H2B by acetylation, phosphorylation and ubiquitination can affect the organisation of the chromatin and gene transcription. There are 16 isoforms of H2B in humans, 13 that are expressed in somatic cells, and 3 that are testis-specific.

Anti-Histone H2B antibody

Cat No. Pack Size Price Qty

crb2005165d

20ug

$150.00

crb2005165f

100ug

$300.00