Anti-Lamin A/C antibody

Description

Recognises human lamin A and C in both Western blots and immunohistochemistry with strong signal and low background

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Application Data

Catalogue number crb2005011
Antibody Anti-Lamin A/C antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200292e
Protein ID UnitProtKB - Q8N519
Cross-Reactivity Human
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA
Target Lamin A/C
Research Area Limb-Girdle muscular dystrophy
Family Intermediate filament (Lamins)
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol, 211(3), 533-551. PMID: 26553927

Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation. Annu Rev Biochem, 84(1), 31-164. PMID: 25747401

 

Santa_Cruz_alternative sc-6214, sc-6215, sc-20681
Nuclear lamin proteins (lamin A, B and C) form a complex structural scaffold, called the nuclear lamina, which is associated with the inside of the nuclear envelope.

Lamins bind to a huge number of nuclear protein complexes and are involved in several processes, including chromatin organisation, gene regulation, genome stability, nuclear and cytoskeletal organisation, mechanical stability, differentiation, and tissue-specific functions. Mutations in lamin proteins result in laminopathies such as muscular dystrophy and the accelerated aging condition, Hutchinson-Gilford progeria.

This antibody recognises human lamin A and C in both Western blots and immunohistochemistry with a strong signal and low background signal.

Anti-Lamin A/C antibody

Cat No. Pack Size Price Qty

crb2005011d

20ug

$150.00

crb2005011f

100ug

$300.00