Anti-NR1 4b antibody

Description

Recognises the 4b splice variant of the NMDA receptor subunit NR1

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Application Data

Catalogue number crb2005008
Antibody Anti-NR1 4b Antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200277e
Protein ID UniProt P35439 (Rat) , UniProt Q05586 (Human)
Aliases NR1, MRD8, NMDAR1, NMDA Zeta-1, NMD-R1, GluN1, glutamate ionotropic receptor NMDA type subunit 1, NMDA NR1 Subunit
Cross-Reactivity Human, Rat, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA
Target NR1 4b, 4d, 4e 4g
Disease Area Neurodegenerative diseases
Family Glutamate-gated ion channel family.
Specificity Rat NR1 4B/D/E/G, Human NR1 Isoform 1/4/6/7
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Donaldson, L. and Beazley-Long, N. (2016). Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discov Today, 21(11), 1787-1798. PMID: 27329269

 

Ewald, R. (2009). Cloning and phylogenetic analysis of NMDA receptor subunits NR1, NR2A and NR2B in Xenopus laevis tadpoles. Front Mol Neurosci, 2. PMID: 19826620

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. NMDARs have been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

The NR1 subunit is alternatively spliced yielding eight possible isoforms characterised by the inclusion or deletion of exons 5, 21 and 22. The splice variants are developmentally and spatially regulated and modulate the biophysical properties of NMDARs and alter the trafficking behaviour of NR1.
NR1-4b Splice variants includes exons 5, 21, and 22 and is expressed in the dorsal horn of the spinal cord.

The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

Anti-NR1 4b antibody

Cat No. Pack Size Price Qty

crb2005008d

20ug

$150.00

crb2005008f

100ug

$300.00