Anti-RAMP1 antibody

Description

Recognises RAMP1, a receptor accessory protein in Western blots and immunohistochemistry with a strong signal and low background noise

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Application Data

Catalogue number crb2005038
Antibody Anti-RAMP1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb120320e
Protein ID UniProtKB - O60894
Cross-Reactivity Human, Rat, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 0.4 mg/ml
Validation 1:200 (WB), 1:100, 1:500, 1:1000 (ELISA), 1:500 (IF)
Target RAMP1
Family RAMP family
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Li, M., Wetzel-Strong, S., Hua, X., Tilley, S., Oswald, E., Krummel, M. and Caron, K. (2014). Deficiency of RAMP1 Attenuates Antigen-Induced Airway Hyperresponsiveness in Mice. PLoS ONE, 9(7), e102356. PMID: 25010197

 

Suekane, A., Saito, Y., Nakahata, S., Ichikawa, T., Ogoh, H., Tsujikawa, K. and Morishita, K. (2019). CGRP-CRLR/RAMP1 signal is important for stress-induced hematopoiesis. Sci Rep, 9(1). PMID: 30674976

Receptor activity-modifying protein 1 (RAMP1) is a receptor accessory protein specifically expressed in hematopoietic progenitor cells. RAMP1 associates with G-protein coupled receptors (GPCRs) to alter ligand specificity and mediate receptor trafficking. RAMP1 forms a receptor complex with calcitonin receptor-like receptor (CRLR) known as the calcitonin gene-related protein (CGRP) receptor.

RAMPs also associate with other family B G-protein coupled receptors including the vasoactive intestinal polypeptide/pituitary AC-activating peptide 1 (VPAC1) receptor and the glucagon receptor (GCGR) where they modulate ligand and G-protein selection.

Anti-RAMP1 antibody

Cat No. Pack Size Price Qty

crb2005038d

20ug

$150.00

crb2005038f

100ug

$300.00