GLT-1 peptide


Antigenic peptide of GLT1, the major glutamate transporter in the mammalian brain

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Catalogue number crb1200000
Antigen Peptide GLT-1 peptide
Protein ID UniProtKB - P43006, P31596
Aliases GLT1, EAAT2 , Excitotoxic Amino Acid Transporter 2, Excitatory Amino Acid Transporter 2, Solute Carrier Family 1 Member 2, Sodium-Dependent Glutamate/Aspartate Transporter 2, Glutamate/Aspartate Transporter II
Cross-Reactivity Human, mouse
Storage -20°C

Al Awabdh, S., Gupta-Agarwal, S., Sheehan, D., Muir, J., Norkett, R., Twelvetrees, A., Griffin, L. and Kittler, J. (2016). Neuronal activity mediated regulation of glutamate transporter GLT-1 surface diffusion in rat astrocytes in dissociated and slice cultures. Glia, 64(7), 1252-1264. PMID: 27189737


Meabon, J., Lee, A., Meeker, K., Bekris, L., Fujimura, R., Yu, C., Watson, G., Pow, D., Sweet, I. and Cook, D. (2011). Differential Expression of the Glutamate Transporter GLT-1 in Pancreas. J Histochem Cytochem, 60(2), 139-151. PMID: 22114258

Specificity Protein
Glutamate transporter 1 (GLT-1) is the major glutamate transporter in the brain, and is predominantly expressed in astrocytes, but at lower levels also in excitatory terminals. GLT-1 is best understood for its critical role in preventing neuronal excitotoxicity and brain seizures in the central nervous system (CNS). Maintaining the correct level of extracellular glutamate is crucial for neuronal transmission and network activity.

Glutamate uptake function allows GLTs/EAATs to terminate and shape excitatory synaptic transmission, and prevent neuronal excitotoxicity. Increasing evidence argues that GLT-1 also modulates, and is modulated by, metabolic processes that influence glucose homeostasis.

GLT-1 peptide

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