Anti-GluR1 antibody

Description

Recognises the GluR1 subunit of AMPAR in Western blots and immunohistochemistry with a clear signal and low background noise

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Application Data

Catalogue number crb2005075
Antibody Anti-GluR1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200335e
Protein ID UniProtKB - P35438
Cross-Reactivity Human, rat, mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation WB/ELISA/IHC
Research Area Neurodegenerative
Family AMPA receptor
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Khatib, T., Whiting, A., Chisholm, D., Redfern, C., Müller, B. and McCaffery, P. (2019). A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor. Mol Neurobiol. PMID: 30972628

 

Spaethling, J., Le, L. and Meaney, D. (2012). NMDA receptor mediated phosphorylation of GluR1 subunits contributes to the appearance of calcium-permeable AMPA receptors after mechanical stretch injury. Neurobiol Dis, 46(3), 646-654. PMID: 22426393

Santa_Cruz_alternative sc-7609, sc-28799

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers. The function of AMPARs is determined by the composition of AMPAR subunits and GluR1 is found in the dorsal horn region of the spinal cord. GluR1-containing AMPARs are permeable to Ca2+ and the presence of GluR1-containing AMPARs in synapses contributes to the formation of long-term potential. GluR1 is involved in synaptic plasticity and the expression of the GluR1 gene is reduced with age.

Anti-GluR1 antibody

Cat No. Pack Size Price Qty

crb2005075d

20ug

$150.00

crb2005075f

100ug

$300.00