Anti-GluR2 antibody

Description

Recognises the GluR2 subunit of AMPAR with a strong signal and low background noise

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Application Data

Catalogue number crb2005076
Antibody Anti-GluR2 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200336e
Protein ID KLH conjugated synthetic peptide crb1200336e
Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2
Cross-Reactivity Rat
Host Species Rabbit
Antibody Type Polyclonal
Label Polyclonal
Concentration 1mg/ml
Validation WB/ELISA
Target GluR2
Research Area Neurodegenerative diseases
Family Glutamate-gated ion channel family.
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Li, D., Byan, H. and Pan, H. (2012). Switch to Glutamate Receptor 2-Lacking AMPA Receptors Increases Neuronal Excitability in Hypothalamus and Sympathetic Drive in Hypertension. J Neurosci, 32(1), 372-380. PMID: 22219297

 

Wang, M., Li, S., Zhang, H., Pei, L., Zou, S., Lee, F., Wang, Y. and Liu, F. (2012). Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity. Mol Brain, 5(1), 13. PMID: 22537872

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.

The function of AMPARs is determined by the composition of AMPAR subunits. GluR2-containing AMPARs have little Ca2+ permeability. The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs.

Defects in expression of GluR2 may be involved to the development of motor neurone disease (MDN/ALS).

Anti-GluR2 antibody

Cat No. Pack Size Price Qty

crb2005076d

20ug

$150.00

crb2005076f

$300.00