Anti-KA1 antibody

Description

Recognises KA1, a kainate glutamate receptor involved in memory and behaviour

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Application Data

Catalogue number crb2005050
Antibody Anti-KA1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200001e
Protein ID UniProtKB - Q01812
Aliases Glutamate receptor ionotropic, kainate 4, Grik4, GluK4, KA1, Glutamate receptor KA-1, KA-1
Cross-Reactivity Mouse, Rat
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:500 (WB), 1:1000 (ELISA)
Target KA1
Family Glutamate-gated ionic channel family
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Fernandes, H., Catches, J., Petralia, R., Copits, B., Xu, J., Russell, T., Swanson, G. and Contractor, A. (2009). High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling. Neuron, 63(6), 818-829. PMID: 19778510

 

Knight, H., Walker, R., James, R., Porteous, D., Muir, W., Blackwood, D. and Pickard, B. (2011). GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status. Am J Med Genet B: Neuropsychiatr Genet, 159B(1), 21-29. PMID: 22052594

Santa_Cruz_alternative sc-8917
Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS), and imbalances in glutamatergic transmission have profound behavioural and physiological consequences. KA1 is a kainate receptor, which are atypical members of the glutamate receptor family able to signal through both ionotropic and metabotropic pathways. KA1 plays a role in memory and behaviour, and aberrant KA1 expression is seen in neurodegeneration, schizophrenia and bipolar disorder.

The KA1 subunit shows very limited and well-defined expression in just a few neuronal cell types after birth. In the hippocampus KA1 mRNA is expressed at high levels in the CA3 pyramidal neurons and at very low levels in granule cells in the dentate gyrus. In all other neurons in the hippocampus, KA1 is absent.

Anti-KA1 antibody

Cat No. Pack Size Price Qty

crb2005050d

20ug

$150.00

crb2005050f

100ug

$300.00