Anti-mGluR2 antibody

Description

Recognises metabotropic glutamate receptor 2, a G protein-coupled receptor involved in glutamate release

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Application Data

Catalogue number crb2005007
Antibody Anti-mGluR2 Antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200279e
Protein ID UniProtKB - Q14416
Aliases GRM2, GPRC1B, MGLUR2, GLUR2, mGlu2, glutamate metabotropic receptor 2, mGluR2
Cross-Reactivity Rat, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ ELISA
Target mGluR2
Research Area Neurodegenerative diseases
Family G-protein coupled receptor 3 family
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Wood, C., Wafford, K., McCarthy, A., Hewes, N., Shanks, E., Lodge, D. and Robinson, E. (2018). Investigating the role of mGluR2 versus mGluR3 in antipsychotic-like effects, sleep-wake architecture and network oscillatory activity using novel Han Wistar rats lacking mGluR2 expression. Neuropharmacology, 140, 246-259. PMID: 30005976

 

Yang, H., Zhang, H., Bi, G., He, Y., Gao, J. and Xi, Z. (2017). Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Cell Rep, 20(2), 319-332. PMID: 28700935

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR2 is a group II receptor, receptors in this group are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivity.

In humans mGluR2 is exclusively expressed in the brain where it is found in neurons as well as astrocytes, predominantly at the presynaptic terminal, although it is also expressed at the postsynaptic terminal. mGluR2 controls glutamate release and is required for generating network oscillations by mediating changes in excitatory and inhibitory neurotransmission through altering NMDA and AMPA receptor function. These oscillations are considered critical for normal central nervous system (CNS) function.

mGluR2 has been linked to the regulation of sleep and sleep disturbances as well as to the development of drug addiction and of psychiatric and neurological disorders. mGluR2 may therefore be a promising target for the treatment of such conditions.

Anti-mGluR2 antibody

Cat No. Pack Size Price Qty

crb2005007d

20ug

$150.00

crb2005007f

100ug

$300.00