Anti-MRGPR-X1 antibody

Description

Recognises MRGPR-X1 in rat and mouse, MRGPR-X1 is a receptor involved in inducing acute pain

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Application Data

Catalogue number crb2005053
Antibody Anti-MRGPR-X1 antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200340e
Protein ID UniProtKB - Q8R4G1
Aliases MAS Related GPR Family Member X1, Sensory Neuron-Specific G-Protein Coupled Receptor 3/4, MAS-Related GPR, Member X1, MRGX1, Mas-Related G-Protein Coupled Receptor Member X1, G Protein-Coupled Receptor MRGX1
Cross-Reactivity Rat, Mouse
Host Species Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target MRGPR-X1
Research Area Inflammatory, Neurological, Cancer
Family MAS Related GPR Family
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Solinski, H., Petermann, F., Rothe, K., Boekhoff, I., Gudermann, T. and Breit, A. (2013). Human Mas-Related G Protein-Coupled Receptors-X1 Induce Chemokine Receptor 2 Expression in Rat Dorsal Root Ganglia Neurons and Release of Chemokine Ligand 2 from the Human LAD-2 Mast Cell Line. PLoS ONE, 8(3), e58756. PMID: 23505557

 

Solinski, H., Zierler, S., Gudermann, T. and Breit, A. (2012). Human Sensory Neuron-specific Mas-related G Protein-coupled Receptors-X1 Sensitize and Directly Activate Transient Receptor Potential Cation Channel V1 via Distinct Signaling Pathways. J Biol Chem, 287(49), 40956-40971. PMID: 23074220

Primate-specific Mas-related G protein-coupled receptor-X1 (MRGPR-X1) is highly enriched in dorsal root ganglia (DRG) neurones as well as in connective tissue mast cells (CTMC) and the leukaemia-derived human mast cell line (LAD)-2. MRGPR-X1 activation induces acute pain and therefore represents a promising target for future pain therapy.

MRGPR-X1 is activated by bovine adrenal medulla peptide-8-22 (BAM 8–22) which is cleaved from pro-enkephalin by pro-hormone convertases. Unlike most if not all Gq-coupled receptors MRGPR-X1 does not undergo agonist-promoted endocytosis.

Anti-MRGPR-X1 antibody

Cat No. Pack Size Price Qty

crb2005053d

20ug

$150.00

crb2005053f

100ug

$300.00