Anti-NR3B antibody

Description

Recognises NR3B subunit from NMDA receptors with a strong signal and low background noise

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Application Data

Catalogue number crb2005052
Antibody Anti-NR3B antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200339e
Protein ID UniProtKB - Q8VHN2
Aliases Glutamate receptor ionotropic, NMDA 3B, GluN3B, Grin3b, N-methyl-D-aspartate receptor subtype 3B, NMDAR3B
Cross-Reactivity Rat, mouse
Host Species Anti-Rabbit
Antibody Type Polyclonal
Concentration 1mg/ml
Validation 1:1000 (WB), 1:1000 (ELISA)
Target NR3B
Disease Area Neurodegenerative diseases
Family Glutamate-gated ion channel family.
Specificity Protein
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References

Ciabarra, A., Sullivan, J., Gahn, L., Pecht, G., Heinemann, S. and Sevarino, K. (1995). Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci, 15(10), 6498-6508. PMID: 7472412

 

Low, C. and Wee, K. (2010). New Insights into the Not-So-New NR3 Subunits of N-Methyl-D-aspartate Receptor: Localization, Structure, and Function. Mol Pharmacol, 78(1), 1-11. PMID: 20363861

 

Prithviraj, R. and Inglis, F. (2008). Expression of the N-methyl-d-aspartate receptor subunit NR3B regulates dendrite morphogenesis in spinal motor neurons. Neuroscience, 155(1), 145-153. PMID: 18541382

Santa_Cruz_alternative sc-55731, sc-50474
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and are important for many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. NMDARs have also been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

The NR3 isoform, NR3B, is abundantly expressed in α-motoneurones and at a lower level in the forebrain (including hippocampus, cerebral cortex, caudoputamen, and nucleus accumbens), and in the cerebellum. mRNA for the NR3B subunit is first detected during the second postnatal week, it then increases and peaks at postnatal day 21. NR3B is a dominant-negative receptor subunit since its presence in NMDA receptors results in a reduction in cellular NMDA receptor activity, calcium permeability, and whole-cell currents.

NR3B plays a role in determining the morphology of dendrites of spinal motor neurones and the proper maturation of motor behaviour. The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

Anti-NR3B antibody

Cat No. Pack Size Price Qty

crb2005052d

20ug

$150.00

crb2005052f

100ug

$300.00