Anti-phosphorylated NR2A (pS1232) antibody

$300.00

Description

NR2 glutamate receptor forms part of the N-methyl D-aspartate 2 (NMDA2, NMDAR2) along with the NR1 subunit which form a heterodimer that make up the NMDA receptor. The NR2 subunit consists of four isoforms NR2A through to NR2D which is the result of alternative splicing of the NR2 gene. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory
Catalogue number crb2005001e
Antibody Anti-phosphorylated NR2A (pS1232) antibody
Antigen Peptide KLH conjugated synthetic peptide crb1200271e
Protein ID UniProtKB - P35436
Aliases GRIN2A, GluN2A, NMDAR2A, NR2A, EIEE27, glutamate ionotropic receptor NMDA type subunit 2A/ NMDA NR2A Subunit
Cross-Reactivity Mouse, Rat
Host Species Anti-Rabbit
Antibody Type Polyclonal
Label Unconjugated
Concentration 1mg/ml
Validation WB/ELISA/IHC
Target phosphorylated NR2A (pS1232)
Research Area Neurodegenerative diseases
Family Glutamate-gated ion channel family.
Super Family Ionotropic receptor
Specificity PTM - Phosphorylated serine 1232
Post-translational Modification Phosphorylation of Serine 1232
Storage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
References Wang et al. (2003). Nature Neuroscience. 6: 1039-1047.
NR2 glutamate receptor forms part of the N-methyl D-aspartate 2 (NMDA2, NMDAR2) along with the NR1 subunit which form a heterodimer that make up the NMDA receptor. The NR2 subunit consists of four isoforms NR2A through to NR2D which is the result of alternative splicing of the NR2 gene. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory

Anti-phosphorylated NR2A (pS1232) antibody