B-Raf peptide

Description

Antigenic peptide of B-raf kinase, a serine/threonine kinase and proto-oncogene involved in directing cell growth

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Catalogue number crb1200381
Antibody Anti-B-Raf antibody
Antigen Peptide B-Raf peptide
Protein ID UniProtKB - P15056
Aliases Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, BRAF, RAFB1, P94, V-Raf Murine Sarcoma Viral Oncogene Homolog B
Cross-Reactivity Human, rat, mouse, chicken
Storage -20°C
References

Eisenhardt, A., Sprenger, A., Röring, M., Herr, R., Weinberg, F., Köhler, M., Braun, S., Orth, J., Diedrich, B., Lanner, U., Tscherwinski, N., Tscherwinski, S., Schuster, S., Dumaz, N., Schmidt, E., Baumeister, R., Schlosser, A., Dengjel, J. and Brummer, T. (2016). Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles. Oncotarget, 7(18). PMID: 27034005

 

Li, Y., Takahashi, M. and Stork, P. (2013). Ras-mutant Cancer Cells Display B-Raf Binding to Ras That Activates Extracellular Signal-regulated Kinase and Is Inhibited by Protein Kinase A Phosphorylation. J Biol Chem, 288(38), 27646-27657. PMID: 23893412

Specificity Protein
B-Raf (BRAF) is a raf-family serine/threonine kinase and proto-oncogene involved in directing cell growth. The Raf kinases are subject to a complex activation process that integrates various protein-protein and protein–lipid interactions and positive as well as negative phosphorylation events. The Ras/Raf/mitogen-activated/extracellular-regulated kinase (MEK)/extracellular signal regulated kinase (ERK) pathway plays a pivotal role in controlling proliferation, survival and differentiation of metazoan cells.

B-Raf, the most potent kinase of the family, plays an important role in various developmental processes. B-Raf is also the most frequently mutated kinase in cancer, making it an important target for cancer treatment, especially in melanoma and hairy cell leukaemia. BRAF mutations are also found in the neuro-cardio-facio-cutaneous syndromes or RASopathies.

B-Raf peptide

Only 1 left

Product Name Qty
B-Raf peptide 50ug 1
Cat No. Pack Size Price Qty

crb1200381e

50ug

$112.50