GluR2 peptide

Description

Antigenic peptide from the GluR2 subunit of AMPAR

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Catalogue number crb1200336
Antigen Peptide GluR2 peptide
Protein ID UniProtKB - Q14416
Aliases GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2
Cross-Reactivity Rat
Storage -20°C
References

Li, D., Byan, H. and Pan, H. (2012). Switch to Glutamate Receptor 2-Lacking AMPA Receptors Increases Neuronal Excitability in Hypothalamus and Sympathetic Drive in Hypertension. J Neurosci, 32(1), 372-380. PMID: 22219297

 

Wang, M., Li, S., Zhang, H., Pei, L., Zou, S., Lee, F., Wang, Y. and Liu, F. (2012). Direct interaction between GluR2 and GAPDH regulates AMPAR-mediated excitotoxicity. Mol Brain, 5(1), 13. PMID: 22537872

Specificity Protein
The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) is an ionotropic transmembrane receptor for glutamate found throughout the central nervous system (CNS). AMPARs are composed of four types of subunits: GluR1/GluA1, GluR2/GluA2, GluR3/GluA3, and GluA4 (GluRA-D2), which combine to form heterotetramers.

The function of AMPARs is determined by the composition of AMPAR subunits. GluR2-containing AMPARs have little Ca2+ permeability. The GluR2 subunit interacts with several proteins and regulates the lysosomal targeting and degradation of AMPARs.

Defects in expression of GluR2 may be involved to the development of motor neurone disease (MDN/ALS).

GluR2 peptide

Cat No. Pack Size Price Qty

crb1200336e

50ug

$112.50