NR1 4b peptide

Description

Antigenic peptide of the 4b splice variant of the NMDA receptor subunit NR1

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Catalogue number crb1200277
Antigen Peptide NR1 4b peptide
Protein ID UniProtKB - Q05586
Aliases NR1, MRD8, NMDAR1, NMDA Zeta-1, NMD-R1, GluN1, glutamate ionotropic receptor NMDA type subunit 1, NMDA NR1 Subunit
Cross-Reactivity Human, Rat, Mouse
Research Area Neurodegenerative diseases
Family glutamate-gated ion channel family
Storage -20°C
References

Donaldson, L. and Beazley-Long, N. (2016). Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discov Today, 21(11), 1787-1798. PMID: 27329269

 

Ewald, R. (2009). Cloning and phylogenetic analysis of NMDA receptor subunits NR1, NR2A and NR2B in Xenopus laevis tadpoles. Front Mol Neurosci, 2. PMID: 19826620

Specificity Protein
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. NMDARs have been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

The NR1 subunit is alternatively spliced yielding eight possible isoforms characterised by the inclusion or deletion of exons 5, 21 and 22. The splice variants are developmentally and spatially regulated and modulate the biophysical properties of NMDARs and alter the trafficking behaviour of NR1.
NR1-4b Splice variants includes exons 5, 21, and 22 and is expressed in the dorsal horn of the spinal cord.

The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

NR1 4b peptide

Cat No. Pack Size Price Qty

crb1200277e

50ug

$112.50