NR3B peptide

Description

Antigenic peptide corresponding to region of the NR3B subunit from NMDA receptors

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Catalogue number crb1200339
Antigen Peptide NR3B peptide
Protein ID UniProtKB - P11474, P62508, O95718
Cross-Reactivity Mouse, rat
Storage -20°C
References

Ciabarra, A., Sullivan, J., Gahn, L., Pecht, G., Heinemann, S. and Sevarino, K. (1995). Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J Neurosci, 15(10), 6498-6508. PMID: 7472412

 

Low, C. and Wee, K. (2010). New Insights into the Not-So-New NR3 Subunits of N-Methyl-D-aspartate Receptor: Localization, Structure, and Function. Mol Pharmacol, 78(1), 1-11. PMID: 20363861

 

Prithviraj, R. and Inglis, F. (2008). Expression of the N-methyl-d-aspartate receptor subunit NR3B regulates dendrite morphogenesis in spinal motor neurons. Neuroscience, 155(1), 145-153. PMID: 18541382

Specificity Protein
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and are important for many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. NMDARs have also been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

The NR3 isoform, NR3B, is abundantly expressed in α-motoneurones and at a lower level in the forebrain (including hippocampus, cerebral cortex, caudoputamen, and nucleus accumbens), and cerebellum. mRNA for the NR3B subunit is first detected during the second postnatal week, it then increases and peaks at postnatal day 21. NR3B is a dominant-negative receptor subunit since its presence in NMDA receptors results in a reduction in cellular NMDA receptor activity, calcium permeability, and whole-cell currents.

NR3B plays a role in determining the morphology of dendrites of spinal motor neurones and the proper maturation of motor behaviour. The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

NR3B peptide

Cat No. Pack Size Price Qty

crb1200339e

50ug

$112.50