Phospho-NR2A (pS1232) peptide


Antigenic peptide from the NR2A subunit of NMDA receptor with phosphorylated ser1232 residue

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Catalogue number crb1200271
Antigen Peptide Phospho-NR2A (pS1232) peptide
Protein ID UniProtKB - Q00959 Rat, P35436 Mouse , Q12879 Human
Aliases GRIN2A, GluN2A, NMDAR2A, NR2A, EIEE27, glutamate ionotropic receptor NMDA type subunit 2A/ NMDA NR2A Subunit
Cross-Reactivity Rat, Mouse, Human
Research Area Neurodegenerative
Family Glutamate-gated ion channel family
Post-translational Modification Phosphorylation of Serine 1232
Storage -20°C

Dong, L., Chen, J., Li, F., Gao, F., Wu, J., Miao, Y. and Wang, Z. (2013). Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina. Neural Plast, 2013, 1-7. PMID: 24175101


Li, B., Sun, M., Zhang, L., Takahashi, S., Ma, W., Vinade, L., Kulkarni, A., Brady, R. and Pant, H. (2001). Regulation of NMDA receptors by cyclin-dependent kinase-5. PNAS, 98(22), 12742-12747. PMID: 11675505

N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ionotropic glutamate receptors that mediate excitatory synaptic transmission and play important roles in many aspects of nervous system function including: synaptic plasticity; learning and memory; neuronal development and circuit formation. In addition NMDARs have also been implicated in various neuronal disorders. NMDARs are heteromers consisting of an obligate NR1 subunit and most commonly one or two kinds of NR2 subunits or occasionally NR3 subunits.

NMDARs are phosphorylated by both serine/threonine and tyrosine kinases. Cyclin dependent kinase-5 (Cdk5) associates with and phosphorylates NR2A subunits at the serine residue at position 1232. Phosphorylation of NR2A at Ser1232 (p-NR2AS1232) by Cdk5/p35 may contribute to neuronal cell death.

The involvement of NMDAR in the central nervous system (CNS) has become a focus area for neurodegenerative diseases such as Alzheimer's disease, epilepsy and ischemic neuronal cell death.

Phospho-NR2A (pS1232) peptide

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