RAF1 peptide

Description

Antigenic peptide corresponding to region in human Raf1 protein

See full description

Catalogue number crb1200405
Antibody Anti-RAF1 antibody
Antigen Peptide RAF1 peptide
Protein ID UniProtKB - P04049
Aliases Raf-1 Proto-Oncogene, Serine/Threonine Kinase, Oncogene RAF1, CRAF, C-Raf
Cross-Reactivity Human
Storage -20°C
References

Buscaino, A., White, S., Houston, D., Lejeune, E., Simmer, F., de Lima Alves, F., Diyora, P., Urano, T., Bayne, E., Rappsilber, J. and Allshire, R. (2012). Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification. PLoS Genetics, 8(2), e1002499. PMID: 22319459

Specificity Protein

Raf1 forms part of the histone H3K9 methyltransferase complex CLRC, along with Clr4, Raf2, Cul4, and Rik1 and is required for heterochromatin formation. CLRC mediates H3K9 methylation, siRNA production and also displays E3-ubiquitin ligase activity in vitro.

Raf1 is a DCAF (DDB1 and CUL4 associated factor) for CLRC. DCAFs act as substrate receptors for E3 ligases and may couple ubiquitination with histone methylation. Raf1 plays an essential role in coupling H3K9 methylation and siRNA production.

RAF1 peptide

Cat No. Pack Size Price Qty

crb1200405e

50ug

$112.50