Grip71 peptide

Description

Antigenic peptide from Grip71, a component of the γ-tubulin ring complex (γ-TuRC) from Drosophila

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Catalogue number crb1200507
Antibody Anti-Grip71 antibody
Antigen Peptide Grip71 peptide
Protein ID UniProtKB - Q9VJ57_DROME
Aliases DGrip71, Dgp71WD
Cross-Reactivity Drosophila melanogaster
Storage -20°C
References

Gunawardane, R., Martin, O. and Zheng, Y. (2003). Characterization of a New γTuRC Subunit with WD Repeats. Mol Biol Cell, 14(3), 1017-1026. PMID: 12631720

 

Romé, P. and Ohkura, H. (2018). A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes. J Cell Biol, 217(10), 3431-3445. PMID: 30087124

Specificity Protein
Grip71 was first identified in Drosophila and named Drosophila gamma ring protein with WD repeats (Dgp71WD). It is a component of the γ-tubulin ring complex (γ-TuRC) and is a homologue of the mammalian NEDD1 (alternatively named GCP-WD). Despite the name, Grip71 lacks Grip domains and instead contains N-terminal WD40 repeats and a C-terminal domain with unknown structure required for Grip71’s association with the γ-TuRC. Grip71 recruits γ-TuRC to different microtubule organising centres (MTOCs).

Grip71 is recruited to the spindle equator and poles by Augmin. In mitotic cells, a loss of Grip71 or Augmin leads to a dramatic decrease in the spindle microtubule density

Grip71 peptide

Cat No. Pack Size Price Qty

crb1200507e

50ug

$127.50