IL-11 peptide

Description

Antigenic peptide from IL-11, a multifunctional haematopoietic cytokine implicated in several normal and pathological processes

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Catalogue number crb1200323
Antibody Anti-IL-11 antibody
Antigen Peptide IL-11 peptide
Protein ID UniProtKB - P20809
Aliases Interleukin-11, adipogenesis inhibitory factor
Cross-Reactivity Human
Storage -20°C
References

Tao, L., Huang, G., Wang, R., Pan, Y., He, Z., Chu, X., Song, H. and Chen, L. (2016). Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway. Sci Rep, 6(1). PMID: 27922075

 

Sokolov, A., Kazakov, A., Solovyev, V., Ismailov, R., Uversky, V., Lapteva, Y., Mikhailov, R., Pavlova, E., Terletskaya, I., Ermolina, L., Permyakov, S. and Permyakov, E. (2016). Expression, Purification, and Characterization of Interleukin-11 Orthologues. Molecules, 21(12), 1632. PMID: 27916836

Specificity Protein
Interleukin-11 (IL-11) is a multifunctional haematopoietic cytokine implicated in several normal and pathological processes. It belongs to the interleukin-6 (IL-6) family of cytokines, which affect intracellular signalling pathways via interaction with the ubiquitously expressed signal-transducing receptor, gp130 and a non-signalling cytokine-specific receptor.

IL-11 is expressed in hepatocytes, B cells, macrophages and osteoclasts and it activates JAK/STAT and MAPK signalling pathways, exerting in some cases drastically different physiological effects. IL-11 favours oncogenesis in numerous overlapping cancer types such as gastrointestinal cancers, breast cancer and osteosarcoma. IL-11 has growth factor activity, immunological activity and plays a role in female fertility control. IL-11 is under investigation for treatment of rheumatoid arthritis, Crohn’s disease, and other inflammatory conditions.

IL-11 peptide

Cat No. Pack Size Price Qty

crb1200323e

50ug

$127.50